Brinsmade Lab
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Lack of CodY leads to biofilm formation in S. aureus
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The Brinsmade Lab is in Regents Hall, which opened in the Summer of 2012
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Cherry blossoms and the Washington Monument as seen from the Tidal Basin
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Single cell analysis of S. aureus gene expression during infection
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Jefferson Memorial and cherry blossoms as seen from the Tidal Basin
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We study how bacterial physiology and pathogenesis are intertwined
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CodY blocks virulence gene expression when nutrients are abundant
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Fluorescently-labeled cells help reveal the mechanism of clumping in codY mutants

Welcome to the Brinsmade Lab at Georgetown University!

We are located in the Department of Biology. Research in the Brinsmade Laboratory seeks to understand how bacteria control pathogenesis using nutritional and host cues during infection. Currently we are focused on the Gram-positive, opportunistic pathogen Staphylococcus aureus.

Recent Papers

  • Mlynek KD, Sause WE, Moormeier DE, Sadykov MR, Hill KR, Torres VJ, Bayles KW, Brinsmade SR. Nutritional regulation of the Sae two-component system by CodY in Staphylococcus aureus J Bacteriol. 2018. (), In press.
  • Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE. Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide. PLoS Genet. 2018. 14(1), e1007159
  • Samuels DJ, Wang Z, Rhee KY, Brinsmade SR. A Tandem Liquid Chromatography-Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus J Vis Exp. 2017. 121(),


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Brinsmade Laboratory
Department of Biology, Georgetown University

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Lab Info
Georgetown University
Department of Biology
301A Regents Hall
37th and O Streets, N.W.
Washington, DC 20057-1229

Shaun Brinsmade, PhD
Assistant Professor

Office: (202) 687-6549